[HTML][HTML] The endocannabinoid system in human keratinocytes: evidence that anandamide inhibits epidermal differentiation through CB1 receptor-dependent inhibition …
M Maccarrone, M Di Rienzo, N Battista… - Journal of Biological …, 2003 - ASBMB
Anandamide (AEA), a prominent member of the endogenous ligands of cannabinoid
receptors (endocannabinoids), is known to affect several functions of brain and peripheral
tissues. A potential role for AEA in skin pathophysiology has been proposed, yet its
molecular basis remains unknown. Here we report unprecedented evidence that
spontaneously immortalized human keratinocytes (HaCaT) and normal human epidermal
keratinocytes (NHEK) have the biochemical machinery to bind and metabolize AEA, ie a …
receptors (endocannabinoids), is known to affect several functions of brain and peripheral
tissues. A potential role for AEA in skin pathophysiology has been proposed, yet its
molecular basis remains unknown. Here we report unprecedented evidence that
spontaneously immortalized human keratinocytes (HaCaT) and normal human epidermal
keratinocytes (NHEK) have the biochemical machinery to bind and metabolize AEA, ie a …