Background: Prurigo nodularis is an eruption of lichenified or excoriated nodules caused by
intractable pruritus that is difficult to treat. Therefore the antipruritic efficacy of capsaicin
seemed to be of particular interest because this alkaloid, extractable from red pepper,
interferes with the perception of pruritus and pain by depletion of neuropeptides in small
sensory cutaneous nerves. Objective: The aim of this concentration-and regimen-ranging
study was to evaluate the efficacy, safety, and practicability of capsaicin in the topical …