Stress-induced analgesia in humans: endogenous opioids and naloxone-reversible depression of pain reflexes
JC Willer, H Dehen, J Cambier - Science, 1981 - science.org
JC Willer, H Dehen, J Cambier
Science, 1981•science.orgThe cumulative effects of a repetitive stress induced by anticipation of pain (noxious foot
shock) were studied on the threshold of a nociceptive flexion reflex of the lower limb. The
threshold of the nociceptive reflex progressively increased with the repetition of the stress.
This effect was reversed by naloxone, which even produced hyperalgesia, since a rapid and
significant decrease in this threshold, below the initial values, was noted. The data provide
evidence for involvement of endogenous opioids in the phenomenon of stress-induced …
shock) were studied on the threshold of a nociceptive flexion reflex of the lower limb. The
threshold of the nociceptive reflex progressively increased with the repetition of the stress.
This effect was reversed by naloxone, which even produced hyperalgesia, since a rapid and
significant decrease in this threshold, below the initial values, was noted. The data provide
evidence for involvement of endogenous opioids in the phenomenon of stress-induced …
The cumulative effects of a repetitive stress induced by anticipation of pain (noxious foot shock) were studied on the threshold of a nociceptive flexion reflex of the lower limb. The threshold of the nociceptive reflex progressively increased with the repetition of the stress. This effect was reversed by naloxone, which even produced hyperalgesia, since a rapid and significant decrease in this threshold, below the initial values, was noted. The data provide evidence for involvement of endogenous opioids in the phenomenon of stress-induced analgesia in normal man.
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