Active “itch fibers” in chronic pruritus
M Schmelz, M Hilliges, R Schmidt, K Ørstavik… - Neurology, 2003 - AAN Enterprises
M Schmelz, M Hilliges, R Schmidt, K Ørstavik, C Vahlquist, C Weidner, HO Handwerker…
Neurology, 2003•AAN EnterprisesAn itch-specific neuronal pathway was recently discovered in healthy humans and animals.
Here the authors report that activity in this specific pathway coincides with itch under
pathophysiologic conditions in a patient with chronic pruritus. Microneurographic recordings
from the symptomatic area revealed spontaneous activity in six single C-fiber afferents that
had the characteristic features of “itch fibers.” Itch may be caused by activity in a specific
subpopulation of C-fiber afferents.
Here the authors report that activity in this specific pathway coincides with itch under
pathophysiologic conditions in a patient with chronic pruritus. Microneurographic recordings
from the symptomatic area revealed spontaneous activity in six single C-fiber afferents that
had the characteristic features of “itch fibers.” Itch may be caused by activity in a specific
subpopulation of C-fiber afferents.
An itch-specific neuronal pathway was recently discovered in healthy humans and animals. Here the authors report that activity in this specific pathway coincides with itch under pathophysiologic conditions in a patient with chronic pruritus. Microneurographic recordings from the symptomatic area revealed spontaneous activity in six single C-fiber afferents that had the characteristic features of “itch fibers.” Itch may be caused by activity in a specific subpopulation of C-fiber afferents.
American Academy of Neurology