[HTML][HTML] Recycling and resensitization of the neurokinin 1 receptor: influence of agonist concentration and Rab GTPases
D Roosterman, GS Cottrell, F Schmidlin… - Journal of Biological …, 2004 - ASBMB
Substance P (SP) induces endocytosis and recycling of the neurokinin 1 receptor (NK1R) in
endothelial cells and spinal neurons at sites of inflammation and pain, and it is thus
important to understand the mechanism and function of receptor trafficking. We investigated
how the SP concentration affects NK1R trafficking and determined the role of Rab GTPases
in trafficking. NK1R trafficking was markedly influenced by the SP concentration. High SP
(10 nm) induced translocation of the NK1R and β-arrestin 1 to perinuclear sorting …
endothelial cells and spinal neurons at sites of inflammation and pain, and it is thus
important to understand the mechanism and function of receptor trafficking. We investigated
how the SP concentration affects NK1R trafficking and determined the role of Rab GTPases
in trafficking. NK1R trafficking was markedly influenced by the SP concentration. High SP
(10 nm) induced translocation of the NK1R and β-arrestin 1 to perinuclear sorting …