[HTML][HTML] Regulation of Wnt signaling during adipogenesis
CN Bennett, SE Ross, KA Longo, L Bajnok… - Journal of Biological …, 2002 - ASBMB
We have identified Wnt10b as a potent inhibitor of adipogenesis that must be suppressed for
preadipocytes to differentiate in vitro. Here, we demonstrate that a specific inhibitor of
glycogen synthase kinase 3, CHIR 99021, mimics Wnt signaling in preadipocytes. CHIR
99021 stabilizes free cytosolic β-catenin and inhibits adipogenesis by blocking induction of
CCAAT/enhancer-binding protein α and peroxisome proliferator-activated receptor γ.
Preadipocyte differentiation is inhibited when 3T3-L1 cells are exposed to CHIR 99021 for …
preadipocytes to differentiate in vitro. Here, we demonstrate that a specific inhibitor of
glycogen synthase kinase 3, CHIR 99021, mimics Wnt signaling in preadipocytes. CHIR
99021 stabilizes free cytosolic β-catenin and inhibits adipogenesis by blocking induction of
CCAAT/enhancer-binding protein α and peroxisome proliferator-activated receptor γ.
Preadipocyte differentiation is inhibited when 3T3-L1 cells are exposed to CHIR 99021 for …