A common major histocompatibility complex class II allele HLA-DQB1* 0301 is present in clinical variants of pemphigoid.

JC Delgado, D Turbay, EJ Yunis… - Proceedings of the …, 1996 - National Acad Sciences
JC Delgado, D Turbay, EJ Yunis, JJ Yunis, ED Morton, K Bhol, R Norman, CA Alper…
Proceedings of the National Academy of Sciences, 1996National Acad Sciences
Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease seen primarily
in elderly persons. It is characterized clinically by the development of tense bullae and by
the presence of an antibasement membrane antibody. In BP, the antigens involved in the
autoimmunity are epidermal basement membrane peptides BPAg1 and BPAg2. We have
compared high resolution typing of major histocompatibility complex class II loci (HLA-
DRB1, DQB1) in 21 patients with BP, 17 with ocular cicatricial pemphigoid (OCP), and 22 …
Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease seen primarily in elderly persons. It is characterized clinically by the development of tense bullae and by the presence of an antibasement membrane antibody. In BP, the antigens involved in the autoimmunity are epidermal basement membrane peptides BPAg1 and BPAg2. We have compared high resolution typing of major histocompatibility complex class II loci (HLA-DRB1, DQB1) in 21 patients with BP, 17 with ocular cicatricial pemphigoid (OCP), and 22 with oral pemphigoid (OP) to a panel of 218 haplotypes of normal individuals. We found that the three diseases (BP, OCP, and OP) have significant association with DQB1*0301 (P = 0.005, P < 0.0001, and P = 0.001, respectively). The frequencies of alleles DQB1*0302, 0303, and 06, which share a specific amino acid sequence from position 71 to 77 (Thr-Arg-Ala-Glu-Leu-Val-Thr) were also increased (P = 0.01). We suggest that an identical major histocompatibility complex class II allele (DQB1*0301) is a common marker for enhanced susceptibility and that the same amino acid residues in positions 71-77 (DQB1*0301, -0302, -0305, -0602, -0603 alleles) are found in patients with BP, OCP and OP. Our findings propose that the autoimmune response in the three different clinical variants of pemphigoid, involves the recognition by T cells of a class II region of DQB1, bound to a peptide from the basement membrane of conjunctiva, oral mucosa, and skin.
National Acad Sciences