T cell receptor gene usage of BP180-specific T lymphocytes from patients with bullous pemphigoid and pemphigoid gestationis
MK Hacker-Foegen, D Zillikens, GJ Giudice, MS Lin - Clinical Immunology, 2004 - Elsevier
BP180 is the autoantigen of different immunobullous diseases, including bullous
pemphigoid (BP) and pemphigoid gestationis (PG). Previously, we demonstrated that the
NC16A domain of this autoantigen harbors key epitopes of autoantibodies and T cells,
indicating that it plays an essential role in the pathogenesis of diseases. Moreover, NC16A-
specific T cell clones derived from these patients were shown to express a CD4+ memory T
cell phenotype and secrete cytokines that may promote autoantibody production. In this …
pemphigoid (BP) and pemphigoid gestationis (PG). Previously, we demonstrated that the
NC16A domain of this autoantigen harbors key epitopes of autoantibodies and T cells,
indicating that it plays an essential role in the pathogenesis of diseases. Moreover, NC16A-
specific T cell clones derived from these patients were shown to express a CD4+ memory T
cell phenotype and secrete cytokines that may promote autoantibody production. In this …