The double regulation of endothelial nitric oxide synthase by caveolae and caveolin: a paradox solved through the study of angiogenesis
E Sbaa, F Frérart, O Feron - Trends in cardiovascular medicine, 2005 - Elsevier
Caveolae are plasmalemmal invaginations formed by the sequestration of cholesterol and
glycosphingolipids with self-associating molecules named caveolins, resulting in a platform
for the assembly of signaling complexes at the surface of the cell. The enrichment of the
endothelial nitric oxide synthase in caveolae and its direct interaction with caveolin both
account for the exquisite regulation of nitric oxide production in cardiovascular tissues.
Dissection of the angiogenic signaling cascade downstream vascular endothelial growth …
glycosphingolipids with self-associating molecules named caveolins, resulting in a platform
for the assembly of signaling complexes at the surface of the cell. The enrichment of the
endothelial nitric oxide synthase in caveolae and its direct interaction with caveolin both
account for the exquisite regulation of nitric oxide production in cardiovascular tissues.
Dissection of the angiogenic signaling cascade downstream vascular endothelial growth …