[HTML][HTML] D6S265*15 marks a DRB1*15, DQB1*0602 haplotype associated with attenuated protection from type 1 diabetes mellitus
AM Valdes, G Thomson, J Graham, M Zarghami… - Diabetologia, 2005 - Springer
Diabetologia, 2005•Springer
Aims/hypothesis The HLA class II DQB1* 0602 allele confers strong dominant protection
against type 1 diabetes but protection is not absolute. The aim of this study was to identify
markers within the HLA region that differentiate DQB1* 0602 haplotypes and show different
associations with disease risk. Methods We defined alleles at eight microsatellite markers
spanning the HLA region in a case-control cohort from Sweden. Results We found that allele
15 at marker D6S265 (109 kb centromeric of HLA-A) was over-represented among patients …
against type 1 diabetes but protection is not absolute. The aim of this study was to identify
markers within the HLA region that differentiate DQB1* 0602 haplotypes and show different
associations with disease risk. Methods We defined alleles at eight microsatellite markers
spanning the HLA region in a case-control cohort from Sweden. Results We found that allele
15 at marker D6S265 (109 kb centromeric of HLA-A) was over-represented among patients …
Aims/hypothesis
The HLA class II DQB1*0602 allele confers strong dominant protection against type 1 diabetes but protection is not absolute. The aim of this study was to identify markers within the HLA region that differentiate DQB1*0602 haplotypes and show different associations with disease risk.
Methods
We defined alleles at eight microsatellite markers spanning the HLA region in a case-control cohort from Sweden.
Results
We found that allele 15 at marker D6S265 (109 kb centromeric of HLA-A) was over-represented among patients carrying DRB1*15, DQB1*0602. A detailed haplotype analysis showed that DRB1*15, DQB1*0602 haplotypes carrying D6S265*15 have a ten-fold higher odds ratio (OR) than those carrying other alleles and thus confer reduced protection [OR D6S265*15=0.186 (95% CI 0.074, 0.472) vs OR D6S265*15−=0.017 (95% CI 0.005, 0.062), p<0.001].
Conclusions/interpretation
Our data support the existence of a locus that modifies the protective effect associated with DQB1*0602. Typing for allele D6S265*15 can identify a less protective DQB1*0602 haplotype, thereby allowing a more accurate prediction of type 1 diabetes risk.
Springer