Meta-analysis of cyclooxygenase-2 inhibitors and their effects on blood pressure
TJ Aw, SJ Haas, D Liew, H Krum - Archives of internal medicine, 2005 - jamanetwork.com
Background Nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) are widely
prescribed and are associated with blood pressure (BP) elevation. The development of
selective cyclooxygenase-2 inhibitors (coxibs) raises the issue of the magnitude of BP
response compared with nonselective NSAIDs. We therefore performed a meta-analysis
comparing the effects of coxibs with placebo, nonselective NSAIDs, and each other on BP
elevation and hypertension. Methods Nineteen randomized controlled trials involving coxibs …
prescribed and are associated with blood pressure (BP) elevation. The development of
selective cyclooxygenase-2 inhibitors (coxibs) raises the issue of the magnitude of BP
response compared with nonselective NSAIDs. We therefore performed a meta-analysis
comparing the effects of coxibs with placebo, nonselective NSAIDs, and each other on BP
elevation and hypertension. Methods Nineteen randomized controlled trials involving coxibs …