[HTML][HTML] Nuclear Factor of Activated T Cells 2 Transactivation in Mast Cells: A NOVEL ISOFORM-SPECIFIC TRANSACTIVATION DOMAIN CONFERS UNIQUE FcϵRI …
MB Hock, MA Brown - Journal of Biological Chemistry, 2003 - ASBMB
Murine nuclear factor of activated T cells (NFAT) 2. α/β differ by 42 and 28 unique amino-
terminal amino acids and are differentially expressed. Both isoforms share conserved
domains that regulate DNA-binding and subcellular localization. A genetic" one-hybrid"
assay was used to define two distinct transactivation (TA) domains: in addition to a
conserved TAD present in both isoforms, a second, novel TAD exists within the β-specific
amino terminus. Pharmacologic inhibitors Gö6976 and rottlerin demonstrate that both …
terminal amino acids and are differentially expressed. Both isoforms share conserved
domains that regulate DNA-binding and subcellular localization. A genetic" one-hybrid"
assay was used to define two distinct transactivation (TA) domains: in addition to a
conserved TAD present in both isoforms, a second, novel TAD exists within the β-specific
amino terminus. Pharmacologic inhibitors Gö6976 and rottlerin demonstrate that both …