Type 1A diabetes mellitus-associated autoimmunity
E Liu, GS Eisenbarth - Endocrinology and metabolism clinics of North …, 2002 - Elsevier
Type 1A diabetes mellitus has become one of the most intensively studied autoimmune
disorders, with characterized animal models and extensive prospective studies of the
development of anti-islet autoimmunity. It is now possible to predict the development of type
1A diabetes mellitus, beginning with HLA-encoded genetic susceptibility, followed by the
development of a series of anti-islet autoantibodies. Prediction is primarily based on the
detection of multiple anti-islet autoantibodies reacting with cloned islet antigens. Multiple …
disorders, with characterized animal models and extensive prospective studies of the
development of anti-islet autoimmunity. It is now possible to predict the development of type
1A diabetes mellitus, beginning with HLA-encoded genetic susceptibility, followed by the
development of a series of anti-islet autoantibodies. Prediction is primarily based on the
detection of multiple anti-islet autoantibodies reacting with cloned islet antigens. Multiple …