[HTML][HTML] Rapid mechanotransduction in situ at the luminal cell surface of vascular endothelium and its caveolae
V Rizzo, A Sung, P Oh, JE Schnitzer - Journal of Biological Chemistry, 1998 - ASBMB
The vascular endothelium is uniquely positioned between the blood and tissue
compartments to receive directly the fluid forces generated by the blood flowing through the
vasculature. These forces invoke specific responses within endothelial cells and serve to
modulate their intrinsic structure and function. The mechanisms by which hemodynamic
forces are detected and converted by endothelia into a sequence of biological and even
pathological responses are presently unknown. By purifying and subfractionating the …
compartments to receive directly the fluid forces generated by the blood flowing through the
vasculature. These forces invoke specific responses within endothelial cells and serve to
modulate their intrinsic structure and function. The mechanisms by which hemodynamic
forces are detected and converted by endothelia into a sequence of biological and even
pathological responses are presently unknown. By purifying and subfractionating the …