Caveolae and caveolins in the cardiovascular system

JP Gratton, P Bernatchez, WC Sessa - Circulation research, 2004 - Am Heart Assoc
JP Gratton, P Bernatchez, WC Sessa
Circulation research, 2004Am Heart Assoc
Caveolae and the caveolae coat proteins, caveolins, are putatively implicated in many
cellular processes, including transcytosis of macromolecules, cholesterol transport, and
signal transduction. Recent insights into the physiological and pathophysiological roles of
these organelles and the caveolins from genetically modified mice suggest that they may be
profoundly important for postnatal cardiovascular function, including endothelial barrier
function, regulation of nitric oxide synthesis, cholesterol metabolism, and cardiac function.
Caveolae and the caveolae coat proteins, caveolins, are putatively implicated in many cellular processes, including transcytosis of macromolecules, cholesterol transport, and signal transduction. Recent insights into the physiological and pathophysiological roles of these organelles and the caveolins from genetically modified mice suggest that they may be profoundly important for postnatal cardiovascular function, including endothelial barrier function, regulation of nitric oxide synthesis, cholesterol metabolism, and cardiac function.
Am Heart Assoc