[HTML][HTML] MAPKs (ERK½, p38) and AKT can be phosphorylated by shear stress independently of platelet endothelial cell adhesion molecule-1 (CD31) in vascular …
BE Sumpio, S Yun, AC Cordova, M Haga… - Journal of Biological …, 2005 - ASBMB
PECAM-1 (CD31) is a member of the Ig superfamily of cell adhesion molecules and is
expressed on endothelial cells (EC) as several circulating blood elements including
platelets, polymorphonuclear leukocytes, monocytes, and lymphocytes. PECAM-1 tyrosine
phosphorylation has been observed following mechanical stimulation of EC but its role in
mechanosensing is still incompletely understood. The aim of this study was to investigate
the involvement of PECAM-1 in signaling cascades in response to fluid shear stress (SS) in …
expressed on endothelial cells (EC) as several circulating blood elements including
platelets, polymorphonuclear leukocytes, monocytes, and lymphocytes. PECAM-1 tyrosine
phosphorylation has been observed following mechanical stimulation of EC but its role in
mechanosensing is still incompletely understood. The aim of this study was to investigate
the involvement of PECAM-1 in signaling cascades in response to fluid shear stress (SS) in …