Age-related changes in albumin binding by renal brush-border membrane vesicles
AL Cessac, M Perichon, J Schaeverbeke… - Mechanisms of ageing …, 1993 - Elsevier
A selective proteinuria occurs with normal aging. We investigated the contribution of a defect
in the receptor-mediated endocytosis to the age-related albuminuria by measuring albumin
binding by renal brush-border membrane vesicles from young and old female Wistar rats
using a filtration method. Old (24 months) rats had a significantly higher proteinuria
(13.29±5.25 mg prot/24 h/100 g bw) than did young (3 months) rats (1.23±0.55 mg prot/24
h/100 g bw). Scatchard analysis of the kinetic parameters of 125 I-albumin binding revealed …
in the receptor-mediated endocytosis to the age-related albuminuria by measuring albumin
binding by renal brush-border membrane vesicles from young and old female Wistar rats
using a filtration method. Old (24 months) rats had a significantly higher proteinuria
(13.29±5.25 mg prot/24 h/100 g bw) than did young (3 months) rats (1.23±0.55 mg prot/24
h/100 g bw). Scatchard analysis of the kinetic parameters of 125 I-albumin binding revealed …