[HTML][HTML] Transgenic overexpression of interleukin (IL)-10 in the lung causes mucus metaplasia, tissue inflammation, and airway remodeling via IL-13-dependent and …

CG Lee, RJ Homer, L Cohn, H Link, S Jung… - Journal of Biological …, 2002 - ASBMB
To address the complex chronic effector properties of interleukin (IL)-10, we generated
transgenic mice in which IL-10 was overexpressed in the lung. In these mice, IL-10 inhibited
endotoxin-induced tumor necrosis factor production and neutrophil accumulation. IL-10 also
caused mucus metaplasia, B and T cell-rich inflammation, and subepithelial fibrosis and
augmented the levels of mRNA encoding Gob-5, mucins, and IL-13. In mice bred to have
null mutations of IL-13, IL-4Rα, or STAT-6, transgenic IL-10 did not induce mucus metaplasia …