[HTML][HTML] Expression of cyp3a4, cyp2b6, andcyp2c9 is regulated by the vitamin d receptor pathway in primary human hepatocytes
L Drocourt, JC Ourlin, JM Pascussi, P Maurel… - Journal of Biological …, 2002 - ASBMB
The fully active dihydroxylated metabolite of vitamin D 3 induces the expression ofCYP3A4
and, to a lesser extent, CYP2B6 andCYP2C9 genes in normal differentiated primary human
hepatocytes. Electrophoretic mobility shift assays and cotransfection in HepG2 cells using
wild-type and mutated oligonucleotides revealed that the vitamin D receptor (VDR) binds
and transactivates those xenobiotic-responsive elements (ER6, DR3, and DR4) previously
identified in CYP3A4, CYP2B6, andCYP2C9 promoters and shown to be targeted by the …
and, to a lesser extent, CYP2B6 andCYP2C9 genes in normal differentiated primary human
hepatocytes. Electrophoretic mobility shift assays and cotransfection in HepG2 cells using
wild-type and mutated oligonucleotides revealed that the vitamin D receptor (VDR) binds
and transactivates those xenobiotic-responsive elements (ER6, DR3, and DR4) previously
identified in CYP3A4, CYP2B6, andCYP2C9 promoters and shown to be targeted by the …