Deletionof Mycobacterium tuberculosis Sigma Factor E Results inDelayed Time to Death with Bacterial Persistence in the Lungsof Aerosol-InfectedMice
M Ando, T Yoshimatsu, C Ko, PJ Converse… - Infection and …, 2003 - Am Soc Microbiol
M Ando, T Yoshimatsu, C Ko, PJ Converse, WR Bishai
Infection and immunity, 2003•Am Soc MicrobiolThe stress-induced extracytoplasmic sigma factor E (SigE) of Mycobacterium tuberculosis
shows increased expression after heat shock, sodium dodecyl sulfate treatment, and
oxidative stress, as well as after phagocytosis in macrophages. We report that deletion of
sigE results in delayed lethality in mice without a significant reduction of bacterial numbers
in lungs.
shows increased expression after heat shock, sodium dodecyl sulfate treatment, and
oxidative stress, as well as after phagocytosis in macrophages. We report that deletion of
sigE results in delayed lethality in mice without a significant reduction of bacterial numbers
in lungs.
Abstract
The stress-induced extracytoplasmic sigma factor E (SigE) of Mycobacterium tuberculosis shows increased expression after heat shock, sodium dodecyl sulfate treatment, and oxidative stress, as well as after phagocytosis in macrophages. We report that deletion of sigE results in delayed lethality in mice without a significant reduction of bacterial numbers in lungs.
American Society for Microbiology