Infection with Mycobacterium tuberculosis remains a major global health emergency.
Although detailed understanding of the molecular events of M. tuberculosis pathogenesis is
still limited, recent genetic analyses have implicated specific lipids of the cell envelope as
important effectors in M. tuberculosis pathogenesis. We have shown that pcaA, a novel
member of a family ofM. tuberculosis S-adenosyl methionine (SAM)-dependent methyl
transferases, is required for α-mycolic acid cyclopropanation and lethal chronic persistentM …