[HTML][HTML] Analysis of the Phthiocerol Dimycocerosate Locus ofMycobacterium tuberculosis: Evidence that this lipid is involved in the cell wall permeability barrier
LR Camacho, P Constant, C Raynaud… - Journal of Biological …, 2001 - ASBMB
Among the few characterized genes that have products involved in the pathogenicity of
Mycobacterium tuberculosis, the etiological agent of tuberculosis, are those of the
phthiocerol dimycocerosate (DIM) locus. Genes involved in biosynthesis of these
compounds are grouped on a 50-kilobase fragment of the chromosome containing 13
genes. Analysis of mRNA produced from this 50-kilobase fragment in the wild type strain
showed that this region is subdivided into three transcriptional units. Biochemical …
Mycobacterium tuberculosis, the etiological agent of tuberculosis, are those of the
phthiocerol dimycocerosate (DIM) locus. Genes involved in biosynthesis of these
compounds are grouped on a 50-kilobase fragment of the chromosome containing 13
genes. Analysis of mRNA produced from this 50-kilobase fragment in the wild type strain
showed that this region is subdivided into three transcriptional units. Biochemical …