Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice
E Dubnau, J Chan, C Raynaud, VP Mohan… - Molecular …, 2000 - Wiley Online Library
E Dubnau, J Chan, C Raynaud, VP Mohan, MA Lanéelle, K Yu, A Quémard, I Smith, M Daffé
Molecular microbiology, 2000•Wiley Online LibraryMembers of the Mycobacterium tuberculosis group synthesize a family of long‐chain fatty
acids, mycolic acids, which are located in the cell envelope. These include the non‐
oxygenated α‐mycolic acid and the oxygenated keto‐and methoxymycolic acids. The
function in bacterial virulence, if any, of these various types of mycolic acids is unknown. We
have constructed a mutant strain of M. tuberculosis with an inactivated hma (cmaA, mma4)
gene; this mutant strain no longer synthesizes oxygenated mycolic acids, has profound …
acids, mycolic acids, which are located in the cell envelope. These include the non‐
oxygenated α‐mycolic acid and the oxygenated keto‐and methoxymycolic acids. The
function in bacterial virulence, if any, of these various types of mycolic acids is unknown. We
have constructed a mutant strain of M. tuberculosis with an inactivated hma (cmaA, mma4)
gene; this mutant strain no longer synthesizes oxygenated mycolic acids, has profound …
Members of the Mycobacterium tuberculosis group synthesize a family of long‐chain fatty acids, mycolic acids, which are located in the cell envelope. These include the non‐oxygenated α‐mycolic acid and the oxygenated keto‐ and methoxymycolic acids. The function in bacterial virulence, if any, of these various types of mycolic acids is unknown. We have constructed a mutant strain of M. tuberculosis with an inactivated hma (cmaA, mma4) gene; this mutant strain no longer synthesizes oxygenated mycolic acids, has profound alterations in its envelope permeability and is attenuated in mice.
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