[HTML][HTML] A neural Wiskott-Aldrich Syndrome protein-mediated pathway for localized activation of actin polymerization that is regulated by cortactin
SJ Kempiak, H Yamaguchi, C Sarmiento… - Journal of Biological …, 2005 - ASBMB
Activation of the epidermal growth factor (EGF) receptor can stimulate actin polymerization
via the Arp2/3 complex using a number of signaling pathways, and specific stimulation
conditions may control which pathways are activated. We have previously shown that
localized stimulation of EGF receptor with EGF bound to beads results in localized actin
polymerization and protrusion. Here we show that the actin polymerization is dependent
upon activation of the Arp2/3 complex by neural Wiskott-Aldrich Syndrome protein (N …
via the Arp2/3 complex using a number of signaling pathways, and specific stimulation
conditions may control which pathways are activated. We have previously shown that
localized stimulation of EGF receptor with EGF bound to beads results in localized actin
polymerization and protrusion. Here we show that the actin polymerization is dependent
upon activation of the Arp2/3 complex by neural Wiskott-Aldrich Syndrome protein (N …