[HTML][HTML] A rho exchange factor mediates thrombin and Gα12-induced cytoskeletal responses
M Majumdar, TM Seasholtz, C Buckmaster… - Journal of Biological …, 1999 - ASBMB
Thrombin induces astrocytoma cell rounding through a Rho-dependent pathway (Majumdar,
M., Seasholtz, TM, Goldstein, D., de Lanerolle, P., and Brown, JH (1998) J. Biol. Chem. 273,
10099–10106). The involvement of the G 12 family of G proteins and the role of specific Rho
exchange factors in transducing signals from the thrombin receptor to Rho-dependent
cytoskeletal responses was examined. Microinjection of cDNAs for activated Gα 12 or Gα 13
induced cell rounding, and antibodies to Gα 12 or Gα 13 blocked the response to thrombin …
M., Seasholtz, TM, Goldstein, D., de Lanerolle, P., and Brown, JH (1998) J. Biol. Chem. 273,
10099–10106). The involvement of the G 12 family of G proteins and the role of specific Rho
exchange factors in transducing signals from the thrombin receptor to Rho-dependent
cytoskeletal responses was examined. Microinjection of cDNAs for activated Gα 12 or Gα 13
induced cell rounding, and antibodies to Gα 12 or Gα 13 blocked the response to thrombin …