[HTML][HTML] Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells
Q Wang, M Liu, T Kozasa, JD Rothstein… - Journal of Biological …, 2004 - ASBMB
Thrombin and lysophosphatidic acid (LPA) receptors play important roles in vascular
biology, development, and cancer. These receptors activate rho via G 12/13 family
heterotrimeric G proteins, which are known to directly activate three distinct rho guanine
nucleotide exchange factors (rhoGEFs) that contain a regulator of G protein signaling (RGS)
domain (RGS-rhoGEFs). However, it is not known which, if any, of these RGS-rhoGEFs
(LARG (leukemia-associated rhoGEF), p115rhoGEF, or PDZrhoGEF) plays a role in G …
biology, development, and cancer. These receptors activate rho via G 12/13 family
heterotrimeric G proteins, which are known to directly activate three distinct rho guanine
nucleotide exchange factors (rhoGEFs) that contain a regulator of G protein signaling (RGS)
domain (RGS-rhoGEFs). However, it is not known which, if any, of these RGS-rhoGEFs
(LARG (leukemia-associated rhoGEF), p115rhoGEF, or PDZrhoGEF) plays a role in G …