Impairment of vascular endothelial function and left ventricular filling: association with the severity of apnea-induced hypoxemia during sleep

H Kraiczi, K Caidahl, A Samuelsson, J Hedner - Chest, 2001 - Elsevier
Study objective To investigate whether a dose-effect relationship exists between the severity
of obstructive sleep apnea (OSA) and subclinical indicators of myocardial or vascular
dysfunction. Design Cross-sectional study using correlation analysis. Participants Twenty
subjects referred to our sleep laboratory for screening or therapy of OSA but without regular
medication and without known cardiovascular disease. Measurements Severity of OSA was
quantified by polysomnography. Moreover, nocturnal excretion of norepinephrine was …