[HTML][HTML] Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-Å resolution
S Ito, K Wakabayashi, O Ubukata, S Hayashi… - Journal of Biological …, 2002 - ASBMB
Bone remodeling involves the resorption of bone by osteoclasts and the synthesis of bone
matrix by osteoblasts. Receptor activator of NF-kB ligand (RANKL, also known as ODF and
OPGL), a member of the tumor necrosis factor (TNF) family, triggers osteoclastogenesis by
forming a complex with its receptor, RANK. We have determined the crystal structure of the
extracellular domain of mouse RANKL at 2.2-Å resolution. The structure reveals that the
RANKL extracellular domain is trimeric, which was also shown by analytical …
matrix by osteoblasts. Receptor activator of NF-kB ligand (RANKL, also known as ODF and
OPGL), a member of the tumor necrosis factor (TNF) family, triggers osteoclastogenesis by
forming a complex with its receptor, RANK. We have determined the crystal structure of the
extracellular domain of mouse RANKL at 2.2-Å resolution. The structure reveals that the
RANKL extracellular domain is trimeric, which was also shown by analytical …