[HTML][HTML] Disabling of receptor activator of nuclear factor-κB (RANK) receptor complex by novel osteoprotegerin-like peptidomimetics restores bone loss in vivo
X Cheng, M Kinosaki, M Takami, Y Choi… - Journal of Biological …, 2004 - ASBMB
The tumor necrosis factor family ligand, tumor necrosis factor-related activation-induced
cytokine (TRANCE), and its receptors, receptor activator of nuclear factor-κB (RANK) and
osteoprotegerin (OPG), are known to be regulators of development and activation of
osteoclasts in bone remodeling. Sustained osteoclast activation that occurs through
TRANCE-RANK causes osteopenic disorders such as osteoporosis and contributes to
osteolytic metastases. Here, we report a rationally designed small molecule mimic of …
cytokine (TRANCE), and its receptors, receptor activator of nuclear factor-κB (RANK) and
osteoprotegerin (OPG), are known to be regulators of development and activation of
osteoclasts in bone remodeling. Sustained osteoclast activation that occurs through
TRANCE-RANK causes osteopenic disorders such as osteoporosis and contributes to
osteolytic metastases. Here, we report a rationally designed small molecule mimic of …