Decreased inositol (1, 4, 5)-trisphosphate receptor levels in Alzheimer's disease cerebral cortex: selectivity of changes and possible correlation to pathological severity
LS Haug, AC Østvold, RF Cowburn, A Garlind… - …, 1996 - Elsevier
We used immunoblotting and radioligand binding techniques to compare levels of the
calcium-mobilizing receptor for the phosphoinositide hydrolysis-derived intracellular second
messenger inositol (1, 4, 5)-trisphosphate (IP3) in post mortem samples from the temporal,
frontal and parietal cortices of eight Alzheimer's disease (AD) and eight matched control
cases. Immunoblotting with an antibody directed against the C-terminal end of the rat type I
IP3-receptor showed that IP3-receptor protein levels were significantly reduced in the …
calcium-mobilizing receptor for the phosphoinositide hydrolysis-derived intracellular second
messenger inositol (1, 4, 5)-trisphosphate (IP3) in post mortem samples from the temporal,
frontal and parietal cortices of eight Alzheimer's disease (AD) and eight matched control
cases. Immunoblotting with an antibody directed against the C-terminal end of the rat type I
IP3-receptor showed that IP3-receptor protein levels were significantly reduced in the …