Brain catecholamines and their metabolites in parkinsonian patients: treatment with levodopa alone or combined with a decarboxylase inhibitor
UK Rinne, V Sonninen - Archives of Neurology, 1973 - jamanetwork.com
Analyses of autopsy samples of parkinsonian patients showed significantly decreased
concentrations of dopamine and homovanillic acid (HVA) in extrapyramidal brain regions.
Twelve patients treated with levodopa alone or combined with a decarboxylase inhibitor
showed concentrations of dopamine and HVA which ranged from values corresponding to
nontreated parkinsonian patients to levels above those in controls. Increase of concentration
of HVA was relatively more marked than that of dopamine. There were no significant …
concentrations of dopamine and homovanillic acid (HVA) in extrapyramidal brain regions.
Twelve patients treated with levodopa alone or combined with a decarboxylase inhibitor
showed concentrations of dopamine and HVA which ranged from values corresponding to
nontreated parkinsonian patients to levels above those in controls. Increase of concentration
of HVA was relatively more marked than that of dopamine. There were no significant …