Recent studies suggest that the long-chain acyl-CoA synthetases (ACS) may play a role in
channeling fatty acids either toward complex lipid synthesis and storage or toward oxidation.
Each of the five members of the ACS family that has been cloned has a distinct tissue
distribution and subcellular location, and is regulated independently during cellular
differentiation and by diverse hormones and nuclear transcription factors including
adrenocorticotropic hormone (ACTH), peroxisomal proliferator-activated receptor-α (PPARα) …