[HTML][HTML] Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet β-cells but not regulated via a positive …
B Wicksteed, C Alarcon, I Briaud, MK Lingohr… - Journal of Biological …, 2003 - ASBMB
Proinsulin biosynthesis is regulated in response to nutrients, most notably glucose. In the
short term (≤ 2h) this is due to increases in the translation of pre-existing mRNA. However,
prolonging glucose stimulation (24 h) also increases preproinsulin mRNA levels. It has been
proposed that secreted insulin from the pancreatic β-cell regulates its own synthesis through
a positive autocrine feedback mechanism. Here the comparative contributions of translation
and mRNA levels on the levels of proinsulin biosynthesis were examined in isolated …
short term (≤ 2h) this is due to increases in the translation of pre-existing mRNA. However,
prolonging glucose stimulation (24 h) also increases preproinsulin mRNA levels. It has been
proposed that secreted insulin from the pancreatic β-cell regulates its own synthesis through
a positive autocrine feedback mechanism. Here the comparative contributions of translation
and mRNA levels on the levels of proinsulin biosynthesis were examined in isolated …