[HTML][HTML] Critical reduction in β-cell mass results in two distinct outcomes over time: adaptation with impaired glucose tolerance or decompensated diabetes
DR Laybutt, M Glandt, G Xu, YB Ahn, N Trivedi… - Journal of Biological …, 2003 - ASBMB
We have proposed that hyperglycemia-induced dedifferentiation of β-cells is a critical factor
for the loss of insulin secretory function in diabetes. Here we examined the effects of the
duration of hyperglycemia on gene expression in islets of partially pancreatectomized (Px)
rats. Islets were isolated, and mRNA was extracted from rats 4 and 14 weeks after Px or
sham Px surgery. Px rats developed different degrees of hyperglycemia; low hyperglycemia
was assigned to Px rats with fed blood glucose levels less than 150 mg/dl, and high …
for the loss of insulin secretory function in diabetes. Here we examined the effects of the
duration of hyperglycemia on gene expression in islets of partially pancreatectomized (Px)
rats. Islets were isolated, and mRNA was extracted from rats 4 and 14 weeks after Px or
sham Px surgery. Px rats developed different degrees of hyperglycemia; low hyperglycemia
was assigned to Px rats with fed blood glucose levels less than 150 mg/dl, and high …