[HTML][HTML] The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases
RL Hurley, KA Anderson, JM Franzone… - Journal of Biological …, 2005 - ASBMB
The AMP-activated protein kinase (AMPK) is an important regulator of cellular metabolism in
response to metabolic stress and to other regulatory signals. AMPK activity is absolutely
dependent upon phosphorylation of AMPKαThr-172 in its activation loop by one or more
AMPK kinases (AMPKKs). The tumor suppressor kinase, LKB1, is a major AMPKK present in
a variety of tissues and cells, but several lines of evidence point to the existence of other
AMPKKs. We have employed three cell lines deficient in LKB1 to study AMPK regulation and …
response to metabolic stress and to other regulatory signals. AMPK activity is absolutely
dependent upon phosphorylation of AMPKαThr-172 in its activation loop by one or more
AMPK kinases (AMPKKs). The tumor suppressor kinase, LKB1, is a major AMPKK present in
a variety of tissues and cells, but several lines of evidence point to the existence of other
AMPKKs. We have employed three cell lines deficient in LKB1 to study AMPK regulation and …