[HTML][HTML] C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase
EK Kim, I Miller, S Aja, LE Landree, M Pinn… - Journal of Biological …, 2004 - ASBMB
Energy homeostasis and feeding are regulated by the central nervous system. C75, a fatty
acid synthase (FAS) inhibitor, causes weight loss and anorexia, implying a novel central
nervous system pathway (s) for sensing energy balance. AMP-activated protein kinase
(AMPK), a sensor of peripheral energy balance, is phosphorylated and activated when
energy sources are low. Here, we identify a role for hypothalamic AMPK in the regulation of
feeding behavior and in mediating the anorexic effects of C75. 5-Aminoimidazole-4 …
acid synthase (FAS) inhibitor, causes weight loss and anorexia, implying a novel central
nervous system pathway (s) for sensing energy balance. AMP-activated protein kinase
(AMPK), a sensor of peripheral energy balance, is phosphorylated and activated when
energy sources are low. Here, we identify a role for hypothalamic AMPK in the regulation of
feeding behavior and in mediating the anorexic effects of C75. 5-Aminoimidazole-4 …