[HTML][HTML] Phosphatidylinositol 3-kinase is required for insulin-stimulated tyrosine phosphorylation of Shc in 3T3-L1 adipocytes
S Ugi, PM Sharma, W Ricketts, T Imamura… - Journal of Biological …, 2002 - ASBMB
The interactions between the phosphatidylinositol 3-kinase (PI 3-kinase) and Ras/MAPK
kinase pathways have been the subject of considerable interest. In the current studies, we
find that epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) lead to
rapid phosphorylation of Shc (maximum at 1–2 min), whereas insulin-mediated Shc
phosphorylation is relatively delayed (maximum at 5–10 min), suggesting that an
intermediary step may be necessary for insulin stimulation of Shc phosphorylation. The Src …
kinase pathways have been the subject of considerable interest. In the current studies, we
find that epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) lead to
rapid phosphorylation of Shc (maximum at 1–2 min), whereas insulin-mediated Shc
phosphorylation is relatively delayed (maximum at 5–10 min), suggesting that an
intermediary step may be necessary for insulin stimulation of Shc phosphorylation. The Src …