[HTML][HTML] Reduction of atherosclerosis by the peroxisome proliferator-activated receptor α agonist fenofibrate in mice

H Duez, YS Chao, M Hernandez, G Torpier… - Journal of Biological …, 2002 - ASBMB
Several clinical and angiographic intervention trials have shown that fibrate treatment leads
to a reduction of the coronary events associated to atherosclerosis. Fibrates are ligands for
peroxisome proliferator-activated receptor α (PPARα) that modulate risk factors related to
atherosclerosis by acting at both systemic and vascular levels. Here, we investigated the
effect of treatment with the PPARα agonist fenofibrate (FF) on the development of
atherosclerotic lesions in apolipoprotein (apo) E-deficient mice and human apoA-I …