A specific inhibitor of the p38 mitogen activated protein kinase affects differentially the production of various cytokines by activated human T cells: dependence on …
S Koprak, MJ Staruch, FJ Dumont - Cellular immunology, 1999 - Elsevier
Cytokine production upon T cell activation results from the integration of multiple signaling
pathways from TCR/CD3 and from costimulatory molecules such as CD28. Among these
pathways, the possible role of p38 mitogen activated protein kinase (MAPK) is the least
understood. Here, we used a highly specific p38 MAPK inhibitor, the SB203580 compound,
to examine the role of this enzyme in the induction of various cytokines in human T cells
stimulated with anti-CD3 and anti-CD28 mAb together or in combination with PMA. Cytokine …
pathways from TCR/CD3 and from costimulatory molecules such as CD28. Among these
pathways, the possible role of p38 mitogen activated protein kinase (MAPK) is the least
understood. Here, we used a highly specific p38 MAPK inhibitor, the SB203580 compound,
to examine the role of this enzyme in the induction of various cytokines in human T cells
stimulated with anti-CD3 and anti-CD28 mAb together or in combination with PMA. Cytokine …