[HTML][HTML] Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2
The mature serine protease Omi/HtrA2 is released from the mitochondria into the cytosol
during apoptosis. Suppression of Omi/HtrA2 by RNA interference in human cell lines
reduces cell death in response to TRAIL and etoposide. In contrast, ectopic expression of
mature wildtype Omi/HtrA2, but not an active site mutant, induces potent caspase activation
and apoptosis. In vitro assays demonstrated that Omi/HtrA2 could degrade inhibitor of
apoptosis proteins (IAPs). Consistent with this observation, increased expression of …
during apoptosis. Suppression of Omi/HtrA2 by RNA interference in human cell lines
reduces cell death in response to TRAIL and etoposide. In contrast, ectopic expression of
mature wildtype Omi/HtrA2, but not an active site mutant, induces potent caspase activation
and apoptosis. In vitro assays demonstrated that Omi/HtrA2 could degrade inhibitor of
apoptosis proteins (IAPs). Consistent with this observation, increased expression of …
