[HTML][HTML] Protein kinase A deficiency causes axially localized neural tube defects in mice
Y Huang, H Roelink, GS McKnight - Journal of Biological Chemistry, 2002 - ASBMB
We have studied the function of protein kinase A (PKA) during embryonic development
using a PKA-deficient mouse that retains only one functional catalytic subunit allele, either
Cα or Cβ, of PKA. The reduced PKA activity results in neural tube defects that are specifically
localized posterior to the forelimb buds and lead to spina bifida. The affected neural tube
has closed appropriately but exhibits an enlarged lumen and abnormal neuroepithelium.
Decreased PKA activity causes dorsal expansion of Sonic hedgehog signal response in the …
using a PKA-deficient mouse that retains only one functional catalytic subunit allele, either
Cα or Cβ, of PKA. The reduced PKA activity results in neural tube defects that are specifically
localized posterior to the forelimb buds and lead to spina bifida. The affected neural tube
has closed appropriately but exhibits an enlarged lumen and abnormal neuroepithelium.
Decreased PKA activity causes dorsal expansion of Sonic hedgehog signal response in the …