Disruption of the MacMARCKS gene prevents cranial neural tube closure and results in anencephaly.
J Chen, S Chang, SA Duncan… - Proceedings of the …, 1996 - National Acad Sciences
Proceedings of the National Academy of Sciences, 1996•National Acad Sciences
MacMARCKS is a member of the MARCKS family of protein kinase C (PKC) substrates.
Biochemical evidence demonstrates that these proteins integrate calcium and PKC-
dependent signals to regulate actin structure at the membrane. We report here that deletion
of the MacMARCKS gene prevents cranial neural tube closure in the developing brain,
resulting in anencephaly. This suggests a central role for MacMARCKS and the PKC signal
transduction pathway in the folding of the anterior neural plate during the early phases of …
Biochemical evidence demonstrates that these proteins integrate calcium and PKC-
dependent signals to regulate actin structure at the membrane. We report here that deletion
of the MacMARCKS gene prevents cranial neural tube closure in the developing brain,
resulting in anencephaly. This suggests a central role for MacMARCKS and the PKC signal
transduction pathway in the folding of the anterior neural plate during the early phases of …
MacMARCKS is a member of the MARCKS family of protein kinase C (PKC) substrates. Biochemical evidence demonstrates that these proteins integrate calcium and PKC-dependent signals to regulate actin structure at the membrane. We report here that deletion of the MacMARCKS gene prevents cranial neural tube closure in the developing brain, resulting in anencephaly. This suggests a central role for MacMARCKS and the PKC signal transduction pathway in the folding of the anterior neural plate during the early phases of brain formation, and supports the hypothesis that actin-based motility directs cranial neural tube closure.
National Acad Sciences