[HTML][HTML] Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils: involvement of Jak2 in the stimulation of …
A Al-Shami, PH Naccache - Journal of Biological Chemistry, 1999 - ASBMB
Granulocyte-macrophage colony-stimulating factor (GM-CSF) regulates many of the
biological activities of human neutrophils. The signaling pathways via which these effects
are mediated are not fully understood. We have shown previously that GM-CSF treatment of
human neutrophils activates the Janus kinase/signal transducers and activators of
transcription (Jak/STAT) pathway and, more specifically, Jak2, STAT3, and STAT5B in
neutrophils. GM-CSF also stimulates the activity of the phosphatidylinositol 3-kinase (PI3 …
biological activities of human neutrophils. The signaling pathways via which these effects
are mediated are not fully understood. We have shown previously that GM-CSF treatment of
human neutrophils activates the Janus kinase/signal transducers and activators of
transcription (Jak/STAT) pathway and, more specifically, Jak2, STAT3, and STAT5B in
neutrophils. GM-CSF also stimulates the activity of the phosphatidylinositol 3-kinase (PI3 …