[HTML][HTML] Ca2+/calmodulin-dependent kinase II and calcineurin play critical roles in endothelin-1-induced cardiomyocyte hypertrophy
W Zhu, Y Zou, I Shiojima, S Kudoh, R Aikawa… - Journal of Biological …, 2000 - ASBMB
Endothelin-1 (ET-1) induces cardiac hypertrophy. Because Ca 2+ is a major second
messenger of ET-1, the role of Ca 2+ in ET-1-induced hypertrophic responses in cultured
cardiac myocytes of neonatal rats was examined. ET-1 activated the promoter of the β-type
myosin heavy chain gene (β-MHC)(− 354 to+ 34 base pairs) by about 4-fold. This activation
was inhibited by chelation of Ca 2+ and the blocking of protein kinase C activity. Similarly,
the β-MHC promoter was activated by Ca 2+ ionophores and a protein kinase C activator. β …
messenger of ET-1, the role of Ca 2+ in ET-1-induced hypertrophic responses in cultured
cardiac myocytes of neonatal rats was examined. ET-1 activated the promoter of the β-type
myosin heavy chain gene (β-MHC)(− 354 to+ 34 base pairs) by about 4-fold. This activation
was inhibited by chelation of Ca 2+ and the blocking of protein kinase C activity. Similarly,
the β-MHC promoter was activated by Ca 2+ ionophores and a protein kinase C activator. β …