[HTML][HTML] The role of Ca2+/calmodulin-dependent protein kinases within the nucleus
EK Heist, H Schulman - Cell calcium, 1998 - Elsevier
Stimulation of cells by Ca2+-linked signaling agents increases Ca2+ levels within both the
cell cytosol and nucleus. The multifunctional Ca2+/calmodulin-dependent protein kinase
(CaM kinase) family, consisting of CaM kinases I, II and IV, have all been detected within the
nucleus and each may serve as a mediator of nuclear Ca2+ signals. Certain isoforms of the
large multimeric CaM kinase II are targeted to the nucleus as a result of an alternatively
spliced nuclear localization signal. By contrast, CaM kinases I and IV are monomeric and …
cell cytosol and nucleus. The multifunctional Ca2+/calmodulin-dependent protein kinase
(CaM kinase) family, consisting of CaM kinases I, II and IV, have all been detected within the
nucleus and each may serve as a mediator of nuclear Ca2+ signals. Certain isoforms of the
large multimeric CaM kinase II are targeted to the nucleus as a result of an alternatively
spliced nuclear localization signal. By contrast, CaM kinases I and IV are monomeric and …