[HTML][HTML] The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking
In C2C12 myoblasts, endogenous histone deacetylase HDAC4 shuttles between
cytoplasmic and nuclear compartments, supporting the hypothesis that its subcellular
localization is dynamically regulated. However, upon differentiation, this dynamic
equilibrium is disturbed and we find that HDAC4 accumulates in the nuclei of myotubes,
suggesting a positive role of nuclear HDAC4 in muscle differentiation. Consistent with the
notion of regulation of HDAC4 intracellular trafficking, we reveal that HDAC4 contains a …
cytoplasmic and nuclear compartments, supporting the hypothesis that its subcellular
localization is dynamically regulated. However, upon differentiation, this dynamic
equilibrium is disturbed and we find that HDAC4 accumulates in the nuclei of myotubes,
suggesting a positive role of nuclear HDAC4 in muscle differentiation. Consistent with the
notion of regulation of HDAC4 intracellular trafficking, we reveal that HDAC4 contains a …