Abstract β-catenin which has a role in E-cadherin mediated cell-to-cell adhesion, and is also
involved in Wnt signaling pathways as a downstream signaling molecule accumulating in
the cytoplasm and nucleus constitutively activates Tcf/LEF-associated transcription of
oncogenic genes. We examined the expression pattern and the genetic alteration of β-
catenin to determine the role of β-catenin in cancer formation and/or progression in
intrahepatic cholangiocarcinoma (ICC). β-catenin expression was immunohistochemically …