Vitamin D and prevention of colorectal cancer
ED Gorham, CF Garland, FC Garland, WB Grant… - The Journal of steroid …, 2005 - Elsevier
ED Gorham, CF Garland, FC Garland, WB Grant, SB Mohr, M Lipkin, HL Newmark…
The Journal of steroid biochemistry and molecular biology, 2005•ElsevierBACKGROUND: Inadequate photosynthesis or oral intake of Vitamin D are associated with
high incidence rates of colorectal cancer, but the dose–response relationship has not been
adequately studied. METHODS: Dose–response gradients from observational studies of
Vitamin D intake and serum 25-hydroxyvitamin D were plotted as trend lines. The point on
each linear trend line corresponding to an odds ratio of 0.50 provided the prediagnostic
Vitamin D intake or 25-hydroxyvitamin D concentration associated with 50% lower risk …
high incidence rates of colorectal cancer, but the dose–response relationship has not been
adequately studied. METHODS: Dose–response gradients from observational studies of
Vitamin D intake and serum 25-hydroxyvitamin D were plotted as trend lines. The point on
each linear trend line corresponding to an odds ratio of 0.50 provided the prediagnostic
Vitamin D intake or 25-hydroxyvitamin D concentration associated with 50% lower risk …
BACKGROUND
Inadequate photosynthesis or oral intake of Vitamin D are associated with high incidence rates of colorectal cancer, but the dose–response relationship has not been adequately studied.
METHODS
Dose–response gradients from observational studies of Vitamin D intake and serum 25-hydroxyvitamin D were plotted as trend lines. The point on each linear trend line corresponding to an odds ratio of 0.50 provided the prediagnostic Vitamin D intake or 25-hydroxyvitamin D concentration associated with 50% lower risk compared to <100IU/day Vitamin D or <13ng/ml serum 25-hydroxyvitamin D. Medians of these values were determined.
RESULTS
Overall, individuals with ≥1000IU/day oral Vitamin D (p<0.0001) or ≥33ng/ml (82nmol/l) serum 25-hydroxyvitamin D (p<0.01) had 50% lower incidence of colorectal cancer compared to reference values.
CONCLUSIONS
Intake of 1000IU/day of Vitamin D, half the safe upper intake established by the National Academy of Sciences, was associated with 50% lower risk. Serum 25-hydroxyvitamin D of 33ng/ml, which is known to be safe, also was associated with 50% lower risk. Prompt public health action is needed to increase intake of Vitamin D3 to 1000IU/day, and to raise 25-hydroxyvitamin D by encouraging a modest duration of sunlight exposure.
Elsevier