[HTML][HTML] Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the …
ED Högestätt, BAG Jönsson, A Ermund… - Journal of Biological …, 2005 - ASBMB
Acetaminophen (paracetamol) is a popular domestic analgesic and antipyretic agent with a
weak anti-inflammatory action and a low incidence of adverse effects as compared with
aspirin and other non-steroidal anti-inflammatory drugs. Here we show that acetaminophen,
following deacetylation to its primary amine, is conjugated with arachidonic acid in the brain
and the spinal cord to form the potent TRPV 1 agonist N-arachidonoylphenolamine
(AM404). This conjugation is absent in mice lacking the enzyme fatty acid amide hydrolase …
weak anti-inflammatory action and a low incidence of adverse effects as compared with
aspirin and other non-steroidal anti-inflammatory drugs. Here we show that acetaminophen,
following deacetylation to its primary amine, is conjugated with arachidonic acid in the brain
and the spinal cord to form the potent TRPV 1 agonist N-arachidonoylphenolamine
(AM404). This conjugation is absent in mice lacking the enzyme fatty acid amide hydrolase …