Although the N-arachidonoyl ethanolamine (anandamide) binds to cannabinoid receptors
and has been implicated in the suppression of pain, its rapid catabolism in vivo by fatty acid
amide hydrolase (FAAH) has presented a challenge in investigating the physiological
functions of this endogenous cannabinoid. In order to test whether anandamide and other
non-cannabinoid fatty amides modulate nociception, we compared FAAH (+/+) and (−/−)
mice in the tail immersion, hot plate, and formalin tests, as well as for thermal hyperalgesia …